For patients with renal disorders, safer alternatives to NSAIDs may include:
Acetaminophen: Generally considered safer for pain relief but lacks anti-inflammatory properties. Topical NSAIDs: These have lower systemic absorption and therefore pose a reduced risk to the kidneys. Non-NSAID analgesics: Medications like tramadol or certain antidepressants may be used for pain management, though they come with their own risks and benefits.