Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the production of prostaglandins, which play a crucial role in maintaining renal blood flow. Reduced prostaglandin levels can lead to decreased blood flow to the kidneys, resulting in reduced glomerular filtration rate (GFR) and potential kidney damage. Chronic use of NSAIDs is particularly risky for individuals with pre-existing kidney conditions or those who are dehydrated.
